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An Fgf/Gremlin Inhibitory Feedback Loop Triggers Termination of Limb Bud Outgrowth

During organ formation and regeneration a proper balance between promoting and restricting growth is critical to achieve stereotypical size. Limb bud outgrowth is driven by signals in a positive feedback loop involving fibroblast growth factor (Fgf) genes, sonic hedgehog (Shh) and Gremlin1 (Grem1)1....

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Detalhes bibliográficos
Main Authors: Verheyden, Jamie M., Sun, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840222/
https://ncbi.nlm.nih.gov/pubmed/18594511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07085
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