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An Fgf/Gremlin Inhibitory Feedback Loop Triggers Termination of Limb Bud Outgrowth
During organ formation and regeneration a proper balance between promoting and restricting growth is critical to achieve stereotypical size. Limb bud outgrowth is driven by signals in a positive feedback loop involving fibroblast growth factor (Fgf) genes, sonic hedgehog (Shh) and Gremlin1 (Grem1)1....
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840222/ https://ncbi.nlm.nih.gov/pubmed/18594511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07085 |
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