Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1

Vertebrate limb outgrowth is driven by a positive feedback loop that involves Sonic hedgehog (Shh) and Gremlin1 (Grem1) in the posterior limb bud mesenchyme and Fibroblast growth factors (Fgfs) in the overlying epithelium. Proper spatio-temporal control of these signaling activities is required to a...

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Detalhes bibliográficos
Main Authors: Farin, Henner F., Lüdtke, Timo H-W., Schmidt, Martina K., Placzko, Susann, Schuster-Gossler, Karin, Petry, Marianne, Christoffels, Vincent M., Kispert, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636256/
https://ncbi.nlm.nih.gov/pubmed/23633963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003467
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