Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1

Vertebrate limb outgrowth is driven by a positive feedback loop that involves Sonic hedgehog (Shh) and Gremlin1 (Grem1) in the posterior limb bud mesenchyme and Fibroblast growth factors (Fgfs) in the overlying epithelium. Proper spatio-temporal control of these signaling activities is required to a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Farin, Henner F., Lüdtke, Timo H-W., Schmidt, Martina K., Placzko, Susann, Schuster-Gossler, Karin, Petry, Marianne, Christoffels, Vincent M., Kispert, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636256/
https://ncbi.nlm.nih.gov/pubmed/23633963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003467
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge