Low-level shRNA Cytotoxicity Can Contribute to MYC-induced Hepatocellular Carcinoma in Adult Mice

Short hairpin RNAs (shRNAs) have emerged as a novel therapeutic modality, but there is increasing concern over nonspecific effects in vivo. Here, we used viral vectors to express shRNAs against endogenous p53 in livers of conditional MYC-transgenic mice. As expected, the shRNAs silenced hepatic p53...

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Bibliographic Details
Main Authors: Beer, Shelly, Bellovin, David I, Lee, Joyce S, Komatsubara, Kimberly, Wang, Lora S, Koh, Huishan, Börner, Kathleen, Storm, Theresa A, Davis, Corrine R, Kay, Mark A, Felsher, Dean W, Grimm, Dirk
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839214/
https://ncbi.nlm.nih.gov/pubmed/19844192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.222
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