Mitochondrial mutational spectra in human cells and tissues

We have found that human organs such as colon, lung, and muscle, as well as their derived tumors, share nearly all mitochondrial hotspot point mutations. Seventeen hotspots, primarily G → A and A → G transitions, have been identified in the mitochondrial sequence of base pairs 10,030–10,130. Mutant...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Khrapko, Konstantin, Coller, Hilary A., André, Paulo C., Li, Xiao-Cheng, Hanekamp, John S., Thilly, William G.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28387/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391107/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13798
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