Mitochondrial mutational spectra in human cells and tissues

We have found that human organs such as colon, lung, and muscle, as well as their derived tumors, share nearly all mitochondrial hotspot point mutations. Seventeen hotspots, primarily G → A and A → G transitions, have been identified in the mitochondrial sequence of base pairs 10,030–10,130. Mutant...

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書誌詳細

出版年:	Proc Natl Acad Sci U S A
主要な著者:	Khrapko, Konstantin, Coller, Hilary A., André, Paulo C., Li, Xiao-Cheng, Hanekamp, John S., Thilly, William G.
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1997
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28387/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391107/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13798
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