PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans

Potential insulin secretagogue properties of an acetoxymethyl ester of a cAMP analog (8-pCPT-2′-O-Me-cAMP-AM) that activates the guanine nucleotide exchange factors Epac1 and Epac2 were assessed using isolated human islets of Langerhans. RT-QPCR demonstrated that the predominant variant of Epac expr...

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Autores principales: Chepurny, Oleg G., Kelley, Grant G., Dzhura, Igor, Leech, Colin A., Roe, Michael W., Dzhura, Elvira, Li, Xiangquan, Schwede, Frank, Genieser, Hans-G., Holz, George G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838523/
https://ncbi.nlm.nih.gov/pubmed/20009023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00630.2009
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