THE CAPSID-SPACER PEPTIDE 1 GAG PROCESSING INTERMEDIATE IS A DOMINANT-NEGATIVE INHIBITOR OF HIV-1 MATURATION

The human immunodeficiency virus type 1 (HIV-1) maturation inhibitor bevirimat disrupts virus replication by inhibiting the cleavage of the capsid-spacer peptide 1 (CA-SP1) Gag processing intermediate to mature CA. The observation that bevirimat delays but does not completely block CA-SP1 processing...

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Bibliographic Details
Main Authors: Checkley, Mary Ann, Luttge, Benjamin G., Soheilian, Ferri, Nagashima, Kunio, Freed, Eric O.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838455/
https://ncbi.nlm.nih.gov/pubmed/20172577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.01.028
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