Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1maturation inhibitor bevirimat

BACKGROUND: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-1-infected patients do not respond to BVM. A...

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Detalhes bibliográficos
Main Authors: Adamson, Catherine S, Sakalian, Michael, Salzwedel, Karl, Freed, Eric O
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873507/
https://ncbi.nlm.nih.gov/pubmed/20406463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-36
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