A Single Polymorphism in HIV-1 Subtype C SP1 Is Sufficient To Confer Natural Resistance to the Maturation Inhibitor Bevirimat

3-O-(3′,3′-Dimethylsuccinyl) betulinic acid (DSB), also known as PA-457, bevirimat (BVM), or MPC-4326, is a novel HIV-1 maturation inhibitor. Unlike protease inhibitors, BVM blocks the cleavage of the Gag capsid precursor (CA-SP1) to mature capsid (CA) protein, resulting in the release of immature,...

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Main Authors: Lu, Wuxun, Salzwedel, Karl, Wang, Dan, Chakravarty, Suvobrata, Freed, Eric O., Wild, Carl T., Li, Feng
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122462/
https://ncbi.nlm.nih.gov/pubmed/21502630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01435-10
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