Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

Abnormal neuronal aggregation of α-synuclein is implicated in the development of many neurological disorders, including Parkinson disease and dementia with Lewy bodies. Glial cells also show extensive α-synuclein pathology and may contribute to disease progression. However, the mechanism that produc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, He-Jin, Suk, Ji-Eun, Patrick, Christina, Bae, Eun-Jin, Cho, Ji-Hoon, Rho, Sangchul, Hwang, Daehee, Masliah, Eliezer, Lee, Seung-Jae
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838344/
https://ncbi.nlm.nih.gov/pubmed/20071342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081125
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