Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABA(A)) Receptors

Enhancement of γ-aminobutyric acid type A receptor (GABA(A)R)-mediated inhibition is a property of most general anesthetics and a candidate for a molecular mechanism of anesthesia. Intravenous anesthetics, including etomidate, propofol, barbiturates, and neuroactive steroids, as well as volatile ane...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Guo-Dong, Chiara, David C., Cohen, Jonathan B., Olsen, Richard W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838283/
https://ncbi.nlm.nih.gov/pubmed/20083606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074708
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