Glycosylation of PrP(C) Determines Timing of Neuroinvasion and Targeting in the Brain following Transmissible Spongiform Encephalopathy Infection by a Peripheral Route

Transmissible spongiform encephalopathy (TSE) infectivity naturally spreads from site of entry in the periphery to the central nervous system where pathological lesions are formed. Several routes and cells within the host have been identified as important for facilitating the infectious process. Exp...

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Bibliographic Details
Main Authors: Cancellotti, Enrico, Bradford, Barry M., Tuzi, Nadia L., Hickey, Raymond D., Brown, Debbie, Brown, Karen L., Barron, Rona M., Kisielewski, Dorothy, Piccardo, Pedro, Manson, Jean C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838100/
https://ncbi.nlm.nih.gov/pubmed/20106922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02374-09
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