Regulation of RB Transcription In Vivo by RB Family Members

In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivated by mutation in the RB gene or functionally inhibited by abnormal activation of cyclin-dependent kinase activity. While variations in RB levels may also provide an important means of controlling RB function in both normal...

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Huvudupphovsmän: Burkhart, Deborah L., Ngai, Lynn K., Roake, Caitlin M., Viatour, Patrick, Thangavel, Chellappagounder, Ho, Victoria M., Knudsen, Erik S., Sage, Julien
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2010
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838078/
https://ncbi.nlm.nih.gov/pubmed/20100864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00952-09
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