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An Oral versus Intranasal Prime/Boost Regimen Using Attenuated Human Rotavirus or VP2 and VP6 Virus-Like Particles with Immunostimulating Complexes Influences Protection and Antibody-Secreting Cell Responses to Rotavirus in a Neonatal Gnotobiotic Pig Model

We determined the impact of mucosal prime/boost regimens and vaccine type (attenuated Wa human rotavirus [AttHRV] or nonreplicating Wa 2/6 rotavirus-like particles [VLP]) on protection and antibody-secreting cell (ASC) responses to HRV in a neonatal gnotobiotic pig disease model. Comparisons of deli...

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Main Authors: Azevedo, Marli S. P., Gonzalez, Ana Maria, Yuan, Lijuan, Jeong, Kwang-il, Iosef, Cristiana, Van Nguyen, Trang, Lovgren-Bengtsson, Karin, Morein, Bror, Saif, Linda J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837955/
https://ncbi.nlm.nih.gov/pubmed/20107005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00395-09
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