Activating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine

BACKGROUND: Response to EGFR-targeted therapies in colorectal cancer patients has been convincingly associated with Kirsten-Ras (K-Ras) mutation status. Current mandatory mutation testing for patient selection is limited to the K-Ras ‘hotspot’ codons 12 and 13. METHODS: Colorectal tumours (n=106) we...

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Hlavní autoři: Smith, G, Bounds, R, Wolf, H, Steele, R J C, Carey, F A, Wolf, C R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837563/
https://ncbi.nlm.nih.gov/pubmed/20147967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605534
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