High frequency of K-ras mutations in sporadic colorectal adenomas.

The frequency of activating mutations at codons 12 and 13 of the K-ras gene was investigated in 57 sporadic adenomas from 47 patients using the polymerase chain reaction and oligonucleotide hybridisation assay. Sixty eight per cent of the adenomas tested were positive for K-ras mutations. This high...

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Main Authors: McLellan, E A, Owen, R A, Stepniewska, K A, Sheffield, J P, Lemoine, N R
Formato: Artigo
Idioma:Inglês
Publicado: 1993
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1374148/
https://ncbi.nlm.nih.gov/pubmed/8472989
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