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Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
Colorectal tumours from MYH polyposis patients display an excess of somatic G : C → T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2410274/ https://ncbi.nlm.nih.gov/pubmed/15083190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601747 |
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