Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer

Colorectal cancer is one of the most significant causes of cancer death. A genetic model for colorectal cancer has been proposed in which the sequential accumulation of mutations in specific genes, including adenomatous polyposis coli (APC), Kirsten-ras (K-ras), and p53, drives the transition from h...

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Main Authors: Smith, Gillian, Carey, Francis A., Beattie, Julie, Wilkie, Murray J. V., Lightfoot, Tracy J., Coxhead, Jonathan, Garner, R. Colin, Steele, Robert J. C., Wolf, C. Roland
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC123158/
https://ncbi.nlm.nih.gov/pubmed/12093899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122612899
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