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Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer

Colorectal cancer is one of the most significant causes of cancer death. A genetic model for colorectal cancer has been proposed in which the sequential accumulation of mutations in specific genes, including adenomatous polyposis coli (APC), Kirsten-ras (K-ras), and p53, drives the transition from h...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Smith, Gillian, Carey, Francis A., Beattie, Julie, Wilkie, Murray J. V., Lightfoot, Tracy J., Coxhead, Jonathan, Garner, R. Colin, Steele, Robert J. C., Wolf, C. Roland
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123158/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093899/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.122612899
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