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Hybrid Scoring and Classification Approaches to Predict Human Pregnane X Receptor Activators
PURPOSE: The human pregnane X receptor (PXR) is a transcriptional regulator of many genes involved in xenobiotic metabolism and excretion. Reliable prediction of high affinity binders with this receptor would be valuable for pharmaceutical drug discovery to predict potential toxicological responses...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836910/ https://ncbi.nlm.nih.gov/pubmed/19115096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9809-7 |
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