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Development and application of hybrid structure based method for efficient screening of ligands binding to G-protein coupled receptors

G-protein coupled receptors (GPCRs) comprise a large superfamily of proteins that are targets for nearly 50% of drugs in clinical use today. In the past, the use of structure-based drug design strategies to develop better drug candidates has been severely hampered due to the absence of the receptor’...

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Bibliografski detalji
Glavni autori: Kortagere, Sandhya, Welsh, William J.
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756463/
https://ncbi.nlm.nih.gov/pubmed/17054015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-006-9077-8
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