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Development and application of hybrid structure based method for efficient screening of ligands binding to G-protein coupled receptors
G-protein coupled receptors (GPCRs) comprise a large superfamily of proteins that are targets for nearly 50% of drugs in clinical use today. In the past, the use of structure-based drug design strategies to develop better drug candidates has been severely hampered due to the absence of the receptor’...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756463/ https://ncbi.nlm.nih.gov/pubmed/17054015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-006-9077-8 |
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