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Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

Structural analyses of the extracellular region of stem cell factor (SCF) receptor (also designated KIT) in complex with SCF revealed a sequence motif in a loop in the fourth Ig-like domain (D4) that is responsible for forming homotypic receptor contacts and for ligand-induced KIT activation and cel...

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Detalhes bibliográficos
Main Authors: Yang, Yan, Xie, Peng, Opatowsky, Yarden, Schlessinger, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836632/
https://ncbi.nlm.nih.gov/pubmed/20080685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914052107
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