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Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells

The ability to target methylation to specific genomic sites would further the study of DNA methylation’s biological role and potentially offer a tool for silencing gene expression and for treating diseases involving abnormal hypomethylation. The end-to-end fusion of DNA methyltransferases to zinc fi...

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Detalhes bibliográficos
Main Authors: Meister, Glenna E., Chandrasegaran, Srinivasan, Ostermeier, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836561/
https://ncbi.nlm.nih.gov/pubmed/20007601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1126
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