Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

The retinoic acid receptor-related orphan receptors α and γ (RORα (NR1F1) and RORγ (NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of development, metabolism, and immune function. Cholesterol and cholesterol sulfate have been suggested to be RORα ligands, but the physi...

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Bibliografski detalji
Glavni autori: Wang, Yongjun, Kumar, Naresh, Solt, Laura A., Richardson, Timothy I., Helvering, Leah M., Crumbley, Christine, Garcia-Ordonez, Ruben D., Stayrook, Keith R., Zhang, Xi, Novick, Scott, Chalmers, Michael J., Griffin, Patrick R., Burris, Thomas P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Gene Regulation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836105/
https://ncbi.nlm.nih.gov/pubmed/19965867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080614
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