Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

The retinoic acid receptor-related orphan receptors α and γ (RORα (NR1F1) and RORγ (NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of development, metabolism, and immune function. Cholesterol and cholesterol sulfate have been suggested to be RORα ligands, but the physi...

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Bibliografiske detaljer
Main Authors: Wang, Yongjun, Kumar, Naresh, Solt, Laura A., Richardson, Timothy I., Helvering, Leah M., Crumbley, Christine, Garcia-Ordonez, Ruben D., Stayrook, Keith R., Zhang, Xi, Novick, Scott, Chalmers, Michael J., Griffin, Patrick R., Burris, Thomas P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836105/
https://ncbi.nlm.nih.gov/pubmed/19965867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080614
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