The Benzenesulfoamide T0901317 [N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] Is a Novel Retinoic Acid Receptor-Related Orphan Receptor-α/γ Inverse Agonist

Retinoic acid receptor-related orphan receptors (RORs) regulate a variety of physiological processes including hepatic gluconeogenesis, lipid metabolism, circadian rhythm, and immune function. Here we present the first high-affinity synthetic ligand for both RORα and RORγ. In a screen against all 48...

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Bibliographische Detailangaben
Hauptverfasser: Kumar, Naresh, Solt, Laura A., Conkright, Juliana J., Wang, Yongjun, Istrate, Monica A., Busby, Scott A., Garcia-Ordonez, Ruben D., Burris, Thomas P., Griffin, Patrick R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812071/
https://ncbi.nlm.nih.gov/pubmed/19887649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.060905
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