Phosphorylation of VACM-1/Cul5 by Protein Kinase A Regulates Its Neddylation and Antiproliferative Effect

Expression of the VACM-1/cul5 gene in endothelial and in cancer cell lines in vitro inhibits cellular proliferation and decreases phosphorylation of MAPK. Structure-function analysis of the VACM-1 protein sequence identified consensus sites specific for phosphorylation by protein kinases A and C (PK...

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Detalhes bibliográficos
Main Authors: Bradley, Shirley E., Johnson, Alyssa E., Le, Isabelle P., Oosterhouse, Elizabeth, Hledin, Michael P., Marquez, Gabriel A., Burnatowska-Hledin, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836093/
https://ncbi.nlm.nih.gov/pubmed/19917606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085225
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