Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases

Constitutive activation of receptor tyrosine kinases (RTKs) is a frequent event in human cancer cells. Activating mutations in Fms-like tyrosine kinase 3 (FLT-3), notably, internal tandem duplications in the juxtamembrane domain (FLT-3 ITD), have been causally linked to acute myeloid leukemia. As we...

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Autors principals: Schmidt-Arras, Dirk-E., Böhmer, Annette, Markova, Boyka, Choudhary, Chunaram, Serve, Hubert, Böhmer, Frank-D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084288/
https://ncbi.nlm.nih.gov/pubmed/15831474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3690-3703.2005
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