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Cross-species Binding Analyses of Mouse and Human Neonatal Fc Receptor Show Dramatic Differences in Immunoglobulin G and Albumin Binding

The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular degradation. Therapeutics and diagnostics built on IgG, Fc, and albumin fusions are frequently evaluated in rodents regarding biodistributio...

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Bibliografiske detaljer
Main Authors: Terje Andersen, Jan, Bekele Daba, Muluneh, Berntzen, Gøril, Michaelsen, Terje E., Sandlie, Inger
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836088/
https://ncbi.nlm.nih.gov/pubmed/20018855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081828
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