Degradation of Some Polyubiquitinated Proteins Requires an Intrinsic Proteasomal Binding Element in the Substrates

Lysine 48-linked polyubiquitin chains usually target proteins for 26 S proteasomal degradation; however, this modification is not a warrant for destruction. Here, we found that efficient degradation of a physiological substrate UbcH10 requires not only an exogenous polyubiquitin chain modification b...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhao, Minglian, Zhang, Nan-Yan, Zurawel, Ashley, Hansen, Kirk C., Liu, Chang-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836082/
https://ncbi.nlm.nih.gov/pubmed/20007692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.060095
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados