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Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code

Insertion of lysine during protein synthesis depends on the enzyme lysyl-tRNA synthetase (LysRS), which exists in two unrelated forms, LysRS1 and LysRS2. LysRS1 has been found in most archaea and some bacteria, and LysRS2 has been found in eukarya, most bacteria, and a few archaea, but the two prote...

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Detalhes bibliográficos
Main Authors: Jester, Brian C., Levengood, Jeffrey D., Roy, Hervé, Ibba, Michael, Devine, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283595/
https://ncbi.nlm.nih.gov/pubmed/14623972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2036253100
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