Beta-lysine discrimination by lysyl-tRNA synthetase

Elongation factor P is modified with (R)- -lysine by the lysyl-tRNA synthetase (LysRS) paralog PoxA. PoxA specificity is orthogonal to LysRS, despite their high similarity. To investigate - and -lysine recognition by LysRS and PoxA, amino acid replacements were made in the LysRS active site guided b...

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Main Authors: Gilreath, Marla S., Roy, Hervé, Bullwinkle, Tammy J., Katz, Assaf, Navarre, William W., Ibba, Michael
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196068/
https://ncbi.nlm.nih.gov/pubmed/21925499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.09.008
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