Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

Apoptosis is a highly regulated form of cell death, characterized by distinctive features such as cellular shrinkage and nuclear condensation. We demonstrate here that proteolytic activation of hPAK65, a p21-activated kinase, induces morphological changes and elicits apoptosis. hPAK65 is cleaved bot...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Lee, Ning, MacDonald, Heather, Reinhard, Christoph, Halenbeck, Robert, Roulston, Anne, Shi, Tim, Williams, Lewis T.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1997
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28359/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391079/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13642
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