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The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism
Human ether à go-go related gene (hERG1) potassium channels underlie the repolarizing I(Kr) current in the heart. Since they are targets of various drugs with cardiac side effects we tested whether the amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) blocks h...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835770/ https://ncbi.nlm.nih.gov/pubmed/20097192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.01.010 |
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