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Platelet and osteoclast β(3) integrins are critical for bone metastasis
Mice with a targeted deletion of β(3) integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of β(3)(+/+) mice by 14 days. In contrast, only 4% of β(3)(...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC283570/ https://ncbi.nlm.nih.gov/pubmed/14612570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2234372100 |
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