Platelet and osteoclast β(3) integrins are critical for bone metastasis

Mice with a targeted deletion of β(3) integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of β(3)(+/+) mice by 14 days. In contrast, only 4% of β(3)(...

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Detaylı Bibliyografya
Yayımlandı:	Proc Natl Acad Sci U S A
Asıl Yazarlar:	Bakewell, Suzanne J., Nestor, Patrick, Prasad, Srinivasa, Tomasson, Michael H., Dowland, Nikki, Mehrotra, Mukund, Scarborough, Robert, Kanter, James, Abe, Keith, Phillips, David, Weilbaecher, Katherine N.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	National Academy of Sciences 2003
Konular:	Biological Sciences
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283570/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14612570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2234372100
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Platelet and osteoclast β(3) integrins are critical for bone metastasis

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