Platelet and osteoclast β(3) integrins are critical for bone metastasis

Mice with a targeted deletion of β(3) integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of β(3)(+/+) mice by 14 days. In contrast, only 4% of β(3)(...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Bakewell, Suzanne J., Nestor, Patrick, Prasad, Srinivasa, Tomasson, Michael H., Dowland, Nikki, Mehrotra, Mukund, Scarborough, Robert, Kanter, James, Abe, Keith, Phillips, David, Weilbaecher, Katherine N.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2003
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283570/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14612570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2234372100
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