In vivo reduction of amyloid-β by a mutant copper transporter

Cu ions have been suggested to enhance the assembly and pathogenic potential of the Alzheimer's disease amyloid-β (Aβ) peptide. To explore this relationship in vivo, toxic-milk (tx(J)) mice with a mutant ATPase7b transporter favoring elevated Cu levels were analyzed in combination with the tran...

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Main Authors: Phinney, Amie L., Drisaldi, Bettina, Schmidt, Stephen D., Lugowski, Stan, Coronado, Veronica, Liang, Yan, Horne, Patrick, Yang, Jing, Sekoulidis, Joannis, Coomaraswamy, Janaky, Chishti, M. Azhar, Cox, Diane W., Mathews, Paul M., Nixon, Ralph A., Carlson, George A., George-Hyslop, Peter St, Westaway, David
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC283568/
https://ncbi.nlm.nih.gov/pubmed/14617772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2332851100
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