In vivo reduction of amyloid-β by a mutant copper transporter

Cu ions have been suggested to enhance the assembly and pathogenic potential of the Alzheimer's disease amyloid-β (Aβ) peptide. To explore this relationship in vivo, toxic-milk (tx(J)) mice with a mutant ATPase7b transporter favoring elevated Cu levels were analyzed in combination with the tran...

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Detalhes bibliográficos
Main Authors: Phinney, Amie L., Drisaldi, Bettina, Schmidt, Stephen D., Lugowski, Stan, Coronado, Veronica, Liang, Yan, Horne, Patrick, Yang, Jing, Sekoulidis, Joannis, Coomaraswamy, Janaky, Chishti, M. Azhar, Cox, Diane W., Mathews, Paul M., Nixon, Ralph A., Carlson, George A., George-Hyslop, Peter St, Westaway, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283568/
https://ncbi.nlm.nih.gov/pubmed/14617772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2332851100
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