ICOS/ICOSL Interaction Is Required for CD4(+) Invariant NKT Cell Function and Homeostatic Survival

The development of airway hyperreactivity (AHR), a cardinal feature of asthma, requires the presence of invariant NKT (iNKT) cells. In a mouse model of asthma, we demonstrated that the induction of AHR required ICOS costimulation of iNKT cells. ICOS was highly expressed on both naive and activated i...

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Bibliographic Details
Main Authors: Akbari, Omid, Stock, Philippe, Meyer, Everett H., Freeman, Gordon J., Sharpe, Arlene H., Umetsu, Dale T., DeKruyff, Rosemarie H.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835525/
https://ncbi.nlm.nih.gov/pubmed/18390727
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