PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions

Interactions of the inhibitory receptor programmed death-1 (PD-1) with its ligands, programmed death ligand (PD-L)1 and PD-L2, regulate T-cell activation and tolerance. In this study, we investigated the role of PD-L1 and PD-L2 in regulating invariant natural killer T (iNKT)-cell-mediated airway hyp...

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Detalhes bibliográficos
Main Authors: Akbari, O, Stock, P, Singh, AK, Lombardi, V, Lee, W-L, Freeman, GJ, Sharpe, AH, Umetsu, DT, DeKruyff, RH
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845714/
https://ncbi.nlm.nih.gov/pubmed/19741598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2009.112
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