Glycolipid activation of invariant T cell receptor(+) NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4(+) T cells

Asthma is an inflammatory lung disease, in which conventional CD4(+) T cells producing IL-4/IL-13 appear to play an obligatory pathogenic role. Here we show, in a mouse model of asthma, that activation of pulmonary IL-4/IL-13 producing invariant TCR(+) CD1d-restricted natural killer T (NKT) cells is...

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Detalhes bibliográficos
Main Authors: Meyer, Everett H., Goya, Sho, Akbari, Omid, Berry, Gerald J., Savage, Paul B., Kronenberg, Mitchell, Nakayama, Toshinori, DeKruyff, Rosemarie H., Umetsu, Dale T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413796/
https://ncbi.nlm.nih.gov/pubmed/16478801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510282103
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