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Intrinsic versus Idiosyncratic Drug-Induced Hepatotoxicity—Two Villains or One?

“Intrinsic” and “idiosyncratic” drug-induced liver injury reactions are commonly thought to arise by different modes of action. Intrinsic toxicity is reproducible in animals and occurs dose-dependently at sublethal doses. Environmental and genetic sensitivity factors can influence the toxicity of in...

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Detaylı Bibliyografya
Asıl Yazarlar: Roth, Robert A., Ganey, Patricia E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835443/
https://ncbi.nlm.nih.gov/pubmed/20019161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.162651
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