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Intrinsic versus Idiosyncratic Drug-Induced Hepatotoxicity—Two Villains or One?
“Intrinsic” and “idiosyncratic” drug-induced liver injury reactions are commonly thought to arise by different modes of action. Intrinsic toxicity is reproducible in animals and occurs dose-dependently at sublethal doses. Environmental and genetic sensitivity factors can influence the toxicity of in...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835443/ https://ncbi.nlm.nih.gov/pubmed/20019161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.162651 |
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