Analysis of Lentiviral Vector Integration in HIV+ Study Subjects Receiving Autologous Infusions of Gene Modified CD4+ T Cells

Lentiviral vector-based gene therapy has been used to target the human immunodeficiency virus (HIV) using an antisense env payload. We have analyzed lentiviral-vector integration sites from three treated individuals. We compared integration sites from the ex vivo vector-transduced CD4+ cell products...

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Detalhes bibliográficos
Main Authors: Wang, Gary P, Levine, Bruce L, Binder, Gwendolyn K, Berry, Charles C, Malani, Nirav, McGarrity, Gary, Tebas, Pablo, June, Carl H, Bushman, Frederic D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835137/
https://ncbi.nlm.nih.gov/pubmed/19259065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.16
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