Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

Gene transfer vectors may cause clonal imbalance and even malignant cell transformation by insertional upregulation of proto-oncogenes. Lentiviral vectors (LV) with their preferred integration in transcribed genes are considered less genotoxic than gammaretroviral vectors (GV) with their preference...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Modlich, Ute, Navarro, Susana, Zychlinski, Daniela, Maetzig, Tobias, Knoess, Sabine, Brugman, Martijn H., Schambach, Axel, Charrier, Sabine, Galy, Anne, Thrasher, Adrian J., Bueren, Juan, Baum, Christopher
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2009
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835038/
https://ncbi.nlm.nih.gov/pubmed/19672245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.179
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires