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Conversion of the allosteric transition of GroEL from concerted to sequential by the single mutation Asp-155 → Ala

The reaction cycle of the double-ring chaperonin GroEL is driven by ATP binding that takes place with positive cooperativity within each seven-membered ring and negative cooperativity between rings. The positive cooperativity within rings is due to ATP binding-induced conformational changes that are...

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Detalhes bibliográficos
Main Authors: Danziger, Oded, Rivenzon-Segal, Dalia, Wolf, Sharon G., Horovitz, Amnon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC283501/
https://ncbi.nlm.nih.gov/pubmed/14615587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2333925100
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