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Concerted ATP-induced allosteric transitions in GroEL facilitate release of protein substrate domains in an all-or-none manner

The double-ring chaperonin GroEL mediates protein folding, in conjunction with its helper protein GroES, by undergoing ATP-induced conformational changes that are concerted within each heptameric ring. Here we have examined whether the concerted nature of these transitions is responsible for protein...

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Bibliografische gegevens
Hoofdauteurs: Kipnis, Yakov, Papo, Niv, Haran, Gilad, Horovitz, Amnon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805612/
https://ncbi.nlm.nih.gov/pubmed/17360617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700070104
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