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φ value analysis of heterogeneity in pathways of allosteric transitions: Evidence for parallel pathways of ATP-induced conformational changes in a GroEL ring

What are the mechanisms of ligand-induced allosteric transitions in proteins? A powerful method to characterize pathways and transition states of reactions is φ value analysis. A φ value is the ratio between the changes on a perturbation (e.g., mutation) in the activation and equilibrium free energi...

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Bibliografiske detaljer
Main Authors: Horovitz, Amnon, Amir, Amnon, Danziger, Oded, Kafri, Galit
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC137842/
https://ncbi.nlm.nih.gov/pubmed/12388779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222303299
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