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Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

RNA interference (RNAi) provides a promising therapeutic approach to human diseases. However, data from recent reports demonstrate that short-hairpin RNAs (shRNAs) may cause cellular toxicity, and this warrants further investigation of the safety of using RNAi vectors. Earlier, in comparing hairpin-...

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書目詳細資料
Main Authors: Boudreau, Ryan L, Martins, Inês, Davidson, Beverly L
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2008
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834985/
https://ncbi.nlm.nih.gov/pubmed/19002161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.231
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